Fig. 5.

Centrality differences (PRFAR-bound – APO) for an exponential damping $\lambda =5$ Å as a function of the residue index (Left) and plotted on top of the protein representation (Right). Red and blue values are regions that, respectively, gain and lose centrality upon PRFAR binding. The domains with higher PRFAR-induced centrality increase are loop1 (HisF: 16–31), f$\alpha$1 (HisF: 31–43), f$\alpha$2 (HisF: 59–72), h$\beta$1 (HisH: 1–5), h$\alpha$1 (HisH: 12–25), and h$\beta$2 (HisH: 30–35).