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Parameters specific to the CYP enzymes and probe substrates
| CYP | kdeg | Substrate | fmCYP |
|---|---|---|---|
| CYP2D6 | Not applicable | Dextromethorphan | 0.72 |
| CYP2B6 | 0.000362 min−1 = 0.0217 h−1 | Bupropion | 0.90 |
| CYP3A4 | 0.000322 min−1 = 0.0193 h−1 | Midazolam | 0.96 |
CYP, cytochrome P450 enzyme; fmCYP, fraction of substrate metabolized by CYP; kdeg, first order degradation rate constant.
