Table 4.
AUC ratios for the respective probe substrates, calculated based on Imax and Iav, respectively, using static modeling
| CYP | AUC ratio (Imax; direct inhibition) | AUC ratio (Imax; TDI) | AUC ratio (Iav; direct inhibition) | AUC ratio (Iav; TDI) |
|---|---|---|---|---|
| Dextromethorphan | 1.11 | N/A | 1.0005 | N/A |
| Bupropion | N/A | 1.32 | N/A | 1.002 |
| Midazolam | 1.91 | 5.93 | 1.76 | 1.78 |
AUC, area under the concentration‐time curve; CYP, cytochrome P450 enzyme; Iav, average inhibitor concentration; Imax, maximum inhibitor concentration; N/A, not applicable; TDI, time dependent inhibition.