Figure 1.
Linked adherence, population pharmacokinetic (PK) and pharmacodynamic (PD) models used in simulations. Adherence model: two‐state (dose taken = 1, dose missed = 0), discrete time, Markov Chain model with transition probabilities (P01, P00, P10, and P11) to simulate adherence patterns. Population PK model: two‐compartment model with first order absorption and elimination parameterized as clearance (CL), central volume (V c), peripheral volume (V p), intercompartmental clearance (Q), and absorption rate constant (K a). PD model: indirect (inhibitory) response model, where drug concentration inhibits the production rate (R 0) and response is cleared by a turnover rate constant of k out.