Table 3.
External validation: Performance of DSI to predict conversion to MCI or any type of dementia when tested in the pooled data of Barcelona and DCN cohorts, for the total cohort and for patients with extreme values
| Variable | % | Stable SCD, n | Progressive SCD, n | AUC | Balanced accuracy | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|---|---|
| Demographics | 232 | 88 | 0.63 | 57.8 | 61.4 | 54.3 | 33.8 | 78.8 | |
| APOE | 203 | 72 | 0.57 | 57.4 | 47.2 | 67.5 | 34.0 | 78.3 | |
| Neuropsychology | 232 | 88 | 0.69 | 63.9 | 63.6 | 64.2 | 40.3 | 82.3 | |
| CSF | 90 | 39 | 0.69 | 61.7 | 59.0 | 64.4 | 41.8 | 78.4 | |
| MRI | 100 | 42 | 0.77 | 67.4 | 73.8 | 61.0 | 44.3 | 84.7 | |
| Demographics + APOE + Neuropsychology + CSF + MRI | 232 | 88 | 0.72 | 65.1 | 68.2 | 62.1 | 40.5 | 83.7 | |
| DSI < 0.2 or DSI > 0.8 | |||||||||
| Demographics + APOE + Neuropsychology + CSF + MRI | 21 | 38 | 30 | 0.81 | 78.5 | 83.3 | 73.7 | 71.4 | 84.8 |
| DSI < 0.3 or DSI > 0.7 | |||||||||
| Demographics + APOE + Neuropsychology + CSF + MRI | 45 | 94 | 50 | 0.79 | 74.2 | 76.0 | 72.3 | 59.4 | 85.0 |
Abbreviations: AUC: area under the receiver operating characteristic curve; PPV, positive predictive value; NPV, negative predictive value; APOE, apolipoprotein E; DSI, Disease State Index; SCD, subjective cognitive decline.
NOTE. For the extreme DSI values, n: number of patients having the DSI value in the given range; %: percentage of patients having the DSI value in the given range. Values are presented as mean.