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. 2018 Dec 29;6:35. doi: 10.1186/s41038-018-0138-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Formation and dissolution of hydrogel based on retro-Michael addition reaction. a Michael addition and retro-Michael reaction. Figure is adapted with permission from the original articles of Konieczynska and Grinstaff [36] (Copyright 2017 by American Chemical Society). b Hydrogel formation using maleimide-functionalized low-molecular weight heparin (MAL-LMWH) and poly(ethylene glycol) (PEG)-thiols; degradation mechanisms for ester and succinimide thioether groups. Figure is adapted with permission from the original articles of Baldwin and Kiick [48] (Copyright 2013 by Royal Society of Chemistry). GSH glutathione, PBS phosphate buffer saline