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. 2018 Dec 29;18:1299. doi: 10.1186/s12885-018-5142-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Compounds D14 and C22 decrease the cellular viability of KRas4B-dependent pancreatic cancer cells. a and b Effect of compounds D14 and C22 at various concentrations (0, 6.25, 12.5, 25, 50, 100 and 200 μM) for 72 h on MIA PaCa-2, BxPC-3 and PanC-1 pancreatic cancer cells and on hTERT-HPNE normal pancreatic cells. The results show the viability inhibition of pancreatic cancer cell induced by the treatments. c Morphological visualization of the MIA PaCa-2 and hTERT-HPNE cell lines treated at 200 μM of compounds D14 and C22