Fig. 6.

The illustration of the present work. PXR translocates from the cytoplasm to the nucleus of the cells when bound to and activated by ligands, then activated PXR binds to target genes’ DNA xenobiotic response elements (XREs) as a heterodimer or heterotetramer with the retinoid X receptor (RXR). Then induce the transcription of the target genes. PXR could be activated by SGD, and then bind to XREs of CYP3A4 and MDR1, induce the transcription of them, finally affect the metabolism of other drugs