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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2018 Sep 24;25(10):906–910. doi: 10.1038/s41594-018-0135-4

Figure 1: The Loop Extrusion Model.

Figure 1:

a, Cohesin complexes load onto the DNA, either randomly or at specific sites, such as CTCF binding sites (purple). b, The cohesin complex reels in DNA, translocating over the DNA and expanding the loop. c, Cohesin complexes stop extruding when they meet a properly oriented CTCF site, leading to a loop between convergently-oriented CTCF anchors.