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Raf domain structure and protein interactions. (A) The Raf kinases can be divided into two functional domains: an amino-terminal regulatory domain and a carboxy-terminal kinase domain and they contain three conserved regions (CRs): CR1, which contains a Ras-binding domain (RBD) and a cysteine-rich domain (CRD); CR2, an area rich in serine/threonine residues (S/T); and CR3, which contains the protein kinase domain. (B) Numerous Raf-binding partners have been identified.
