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Regulation of the Raf kinases by phosphorylation. (Top) Raf is both positively and negatively regulated by phosphorylation on numerous sites. (Bottom) Shown are the amino acid sequence alignments of the sites of Raf phosphorylation, with the residues phosphorylated shown in red, and the relevant kinases indicated above the sequences. A glutamic acid residue that can act as a phosphomimetic to promote the active conformation of the activation segment (AS) is also shown in green.
