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. 2018 Dec 29;15(1):2. doi: 10.1007/s11306-018-1457-2

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — a Protein assay: Ratio of significantly (p < 0.05) identified proteins are sub-grouped as early and late groups. The common proteins between the two groups is shown in overlapping regions. b Integrative gene-metabolite network: Significant genes identified from blood samples in previously published manuscript (Hammamieh et al. 2016) and metabolites were combined from all of the time points for integrated analysis. The larger node size reflects the modularity. Interaction networks were constituted from differentially regulated transcripts (blue colored nodes = down-regulated transcripts; red colored nodes = up-regulated transcripts) and differentially altered metabolites (green nodes = decreased metabolites; magenta colored nodes = elevated metabolites)

Fig. 4 — a Protein assay: Ratio of significantly (p < 0.05) identified proteins are sub-grouped as early and late groups. The common proteins between the two groups is shown in overlapping regions. b Integrative gene-metabolite network: Significant genes identified from blood samples in previously published manuscript (Hammamieh et al. 2016) and metabolites were combined from all of the time points for integrated analysis. The larger node size reflects the modularity. Interaction networks were constituted from differentially regulated transcripts (blue colored nodes = down-regulated transcripts; red colored nodes = up-regulated transcripts) and differentially altered metabolites (green nodes = decreased metabolites; magenta colored nodes = elevated metabolites)