Table 1.
Effect of various E. Japonica leaf extracts and fractions on serum marker enzymes in control and experimental rats.
| Parameters | Groups | ||||
|---|---|---|---|---|---|
|
AST U/L |
ALT U/L |
ALP U/L |
GGT (U/L) |
Bilirubin (g/dL) | |
| Normal | 107.33±3.09 | 26.08±1.51 | 341.00±7.13 | 5.71±0.24 | 0.57±0.01 |
| CCl 4 | 339.16±5.28∗∗∗a | 301.00±6.00∗∗∗a | 586.33±7.77∗∗∗a | 17.70±0.87∗∗∗a | 2.94±0.06∗∗∗a |
| Silymarin 10 mg/kg + CCl 4 | 154.66±4.95∗∗∗b | 88.15±6.47∗∗∗b | 396.6±711.61∗∗∗b | 7.31±0.21∗∗∗b | 1.00±0.04∗∗∗b |
| Er-1 250 mg/kg + CCl 4 | 333.66±5.25b | 295.83±5.24b | 584.50±7.96b | 15.66±0.55b | 2.95±0.04b |
| Er-1 500mg/kg + CCl 4 | 314.33±5.40∗b | 291.66±5.09b | 570.00±8.70b | 15.23±0.35∗b | 2.79±0.04b |
| Er-2 250mg/kg + CCl 4 | 278.33±6.08∗∗∗b | 196.50±6.33∗∗∗b | 492.3±5.2∗∗∗b | 12.71±0.35∗∗∗b | 1.85±0.06∗∗∗b |
| Er-2 500mg/kg + CCl 4 | 194.16±5.46∗∗∗b | 156.66±5.32∗∗∗b | 441.0±6.24∗∗∗b | 10.41±0.26∗∗∗b | 1.40±0.03∗∗∗b |
| Er-3 250mg/kg + CCl 4 | 265.50±8.55∗∗∗b | 170.16±7.21∗∗∗b | 468.0±8.1∗∗∗b | 10.11±0.24∗∗∗b | 1.81±0.07∗∗∗b |
| Er-3 500mg/kg + CCl 4 | 198.50±4.77∗∗∗b | 137.16±3.09∗∗∗b | 428.1±6.44∗∗∗b | 8.55±0.35∗∗∗b | 1.23±0.05∗∗∗b |
| Er-4 250 mg/kg + CCl 4 | 318.50±8.00b | 310.50±4.50b | 594.50±7.39b | 16.76±0.53b | 2.98±0.04b |
| Er-4 500 mg/kg + CCl 4 | 297.3±5.14∗∗∗b | 292.33±5.00b | 582.83±15.47b | 16.06±0.84b | 2.82±0.05b |
All values represent mean ± SEM. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ANOVA. aAs compared to that of the normal control group; bas compared to that of the CCl4 positive control group.