Table 2.
Effect of E. Japonica leaf extract and fractions on metabolism and serum lipoproteins in control and experimental rats.
| Parameters | Groups | ||||
|---|---|---|---|---|---|
| Cholesterol (mg/dL) | Triglycerides (mg/dL) |
HDL (mg/dL) |
LDL (mg/dL) |
VLDL (mg/dL) |
|
| Normal | 108.3±3.08 | 81.88±2.41 | 47.56±1.14 | 44.39±3.09 | 16.37±0.48 |
| CCl 4 | 231.5±8.5∗∗∗a | 187.83±3.87∗∗∗a | 22.93±0.95∗∗∗a | 171.0±8.19∗∗∗a | 37.56±0.77∗∗∗a |
| Silymarin 10 mg/kg + CCl 4 | 128.5±3.5∗∗∗b | 104.51±3.56∗∗∗b | 44.6±1.30∗∗∗b | 62.9±3.5∗∗∗b | 20.90±0.77∗∗∗b |
| Er-1 250 mg/kg + CCl 4 | 223.0±4.78b | 192.83±4.85b | 24.91±0.54b | 159.5±4.3b | 38.56±0.97b |
| Er-1 500 mg/kg + CCl 4 | 211.16±4.4b | 187.5±5.2b | 26.43±0.39∗∗b | 147.23±3.76∗b | 37.50±1.04b |
| Er-2 250 mg/kg + CCl 4 | 186.1±4.5∗∗∗b | 157.5±3.7∗∗∗b | 31.4±1.0∗∗∗b | 123.1±4.7∗∗∗b | 31.50±0.74∗∗∗b |
| Er-2 500 mg/kg + CCl 4 | 155.5±4.1∗∗∗b | 137.0±3.8∗∗∗b | 38.40±0.89∗∗∗b | 89.7±4.11∗∗∗b | 27.4±0.77∗∗∗b |
| Er-3 250 mg/kg + CCl 4 | 150.3±3.3∗∗∗b | 128.6±3.4∗∗∗b | 35.41±0.88∗∗∗b | 89.1±4.19∗∗∗b | 25.72±0.76∗∗∗b |
| Er-3 500 mg/kg + CCl 4 | 129.6±8.3∗∗∗b | 125.8±3.4±∗∗∗b | 40.81±1.21∗∗∗b | 63.6±3.8∗∗∗b | 25.16±0.68∗∗∗b |
| Er-4 250 mg/kg + CCl 4 | 219.83±7.5b | 180.16±7.4b | 25.58±1.13b | 161.2±9.4b | 36.03±1.48b |
| Er-4 500 mg/kg + CCl 4 | 215.66±4.4b | 166.33±5.16∗b | 27.58±0.92∗∗b | 154.8±4.8b | 33.26±1.03∗∗b |
All values represent mean ± SEM. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ANOVA, followed by Dennett's multiple comparison test. aAs compared to that of the control group; bas compared to that of the CCl4 positive control group.