Table 3.
Final models for predicting death in SLS I
| FVC Models | |||
|---|---|---|---|
| Cox Model using Baseline FVC as covariate |
Cox Model using FVC as time- dependent covariate |
Joint model usig FVC as a time- dependent covariate |
|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Baseline MRSS | 1.03 (1.01, 1.05)* | 1.03 (1.01, 1.06)** | 1.03 (1.01, 1.06)** |
| Age (years) | 1.06 (1.04, 1.08)**** | 1.06 (1.04, 1.08)**** | 1.06 (1.03, 1.08)**** |
| FVC%-predicted | 0.97 (0.95, 0.99)** | 0.96 (0.94, 0.97)**** | 0.97 (0.96, 0.98)**** |
| AIC | 564 | 546 | 789 |
| DLCO Models | |||
|---|---|---|---|
| Cox Model using Baseline DLCO as covariate |
Cox Model using DLCO as time- dependent covariate |
Joint model usig DLCO as a time- dependent covariate |
|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Baseline MRSS | 1.04 (1.01, 1.06)** | 1.04 (1.02, 1.07)** | 1.04 (1.01, 1.06)** |
| Age (years) | 1.05 (1.03, 1.08)**** | 1.05 (1.02, 1.07)**** | 1.05 (1.03, 1.07)**** |
| DLCO%-predicted | 0.98 (0.96, 1.00) | 0.96 (0.95, 0.98)**** | 0.96 (0.94, 0.98)**** |
| AIC | 569 | 525 | 791 |
*
P<0.05
**
P<0.01
***
P<0.001
****
P<0.0001
Definitions of abbreviations: HR = hazards ratio; AIC = Akaike information criterion; FVC = forced vital capacity; DLCO = single-breath diffusing capacity for carbon monoxide; MRSS = Modified Rodnan Skin Score.