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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Ann Rheum Dis. 2018 Nov 8;78(1):122–130. doi: 10.1136/annrheumdis-2018-213708

Table 3.

Final models for predicting death in SLS I

FVC Models
Cox Model using
Baseline FVC as
covariate
Cox Model using
FVC as time-
dependent covariate
Joint model usig
FVC as a time-
dependent covariate
HR (95% CI) HR (95% CI) HR (95% CI)
Baseline MRSS 1.03 (1.01, 1.05)* 1.03 (1.01, 1.06)** 1.03 (1.01, 1.06)**
Age (years) 1.06 (1.04, 1.08)**** 1.06 (1.04, 1.08)**** 1.06 (1.03, 1.08)****
FVC%-predicted 0.97 (0.95, 0.99)** 0.96 (0.94, 0.97)**** 0.97 (0.96, 0.98)****
AIC 564 546 789
DLCO Models
Cox Model using
Baseline DLCO as
covariate
Cox Model using DLCO
as time-
dependent covariate
Joint model usig
DLCO as a time-
dependent covariate
HR (95% CI) HR (95% CI) HR (95% CI)
Baseline MRSS 1.04 (1.01, 1.06)** 1.04 (1.02, 1.07)** 1.04 (1.01, 1.06)**
Age (years) 1.05 (1.03, 1.08)**** 1.05 (1.02, 1.07)**** 1.05 (1.03, 1.07)****
DLCO%-predicted 0.98 (0.96, 1.00) 0.96 (0.95, 0.98)**** 0.96 (0.94, 0.98)****
AIC 569 525 791
*

P<0.05

**

P<0.01

***

P<0.001

****

P<0.0001

Definitions of abbreviations: HR = hazards ratio; AIC = Akaike information criterion; FVC = forced vital capacity; DLCO = single-breath diffusing capacity for carbon monoxide; MRSS = Modified Rodnan Skin Score.