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Experimental Design. Male Fmr1 knockout (KO) and wild-type (WT) were given free access to a running dish or wheel starting at either postnatal day (PND) 29 or PND49 for 1 week (short-term running) or 4 weeks (long-term running). To study the effect of long-term running on cell survival, mice were injected with BrdU (100 mg/kg) daily for 3 days prior to voluntary running in order to labelproliferating cells.
