Table 1.

Summary of the binding-kinetics parameters measured for H. pylori HtrA, and physicochemical properties of compounds 1a and 2.

Compound	KD [μm]	koff [s−1]	t1/2 [s]	LE[a]	logP[b]	logS[b]
1a	27 ± 4	1.4	0.5	0.22	4.8	−8.7
2	37 ± 4	1.8	0.4	0.24	3.5	−4.3

^[a]Ligand efficiency (= −1.4 logK_D/(number of non-hydrogen atoms)).

^[b]Octanol–water partition coefficient P and aqueous solubility S calculated with MOE 2011.10.