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. Author manuscript; available in PMC: 2018 Dec 30.
Published in final edited form as: Angew Chem Int Ed Engl. 2017 Aug 15;56(40):12052–12063. doi: 10.1002/anie.201701065

Figure 12.

Figure 12

Example of splicing selectivity at the protein level. a) Mechanism of splicing modulation in MCL1. b) MCL1 splicing in mantel cell lymphoma (MCL-B) cells after treatment with control (<M->) or 100 nm 1, 3, or 24 for 4 h. The levels of spliced (S) and unspliced (L) transcripts were evaluated by RT-PCR analysis. Without splicing modulation, MCL1 undergoes normal splicing leaving the longer form. Treatment with 1, 3, or 24 results in exon skipping as noted by the formation of the shorter form.