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Topological map of all known TS, COTS, and LQTS-associated CACNA1C mutations. 4 homologous domains are designated (DI-DIV) comprised of transmembrane segments (columns), cytoplasmic segments, and transmembrane linker segments. TS- (yellow fill), COTS- (red fill), and LQTS-associated (white fill) mutations are overlaid the linear topology of the CACNA1C. The CACNA1C-L762F mutation is noted in blue outline.
