. Author manuscript; available in PMC: 2018 Dec 30.

Published in final edited form as: Int J Cardiol. 2016 Jun 23;220:290–298. doi: 10.1016/j.ijcard.2016.06.081

Table 3.

Comparison of Timothy syndrome, cardiac-only Timothy syndrome, and long QT syndrome probands in the literature.

	TS	COTS	LQTS	Total	P-value^a
Probands	9	3	16	28
Mutations	4	2	14	20
Age (y)	2.15 ± 0.85	20.0 ± 5.0	19.1 ± 3.3	13.7 ± 2.5	0.001
% female	44%	100%	75%	68%	0.2
QTc	650 ± 29	493 ± 7	486 ± 10	539 ± 18	<0.0001
AV block	66%	0%	0%	25%	0.0024
SCD	55%	33%	31%	39%	0.12
Fam Hx	11%	100%	44%	39%	0.39
Fam Hx SCD	0%	33%	19%	14%	0.28

TS vs LQTS cohorts; COTS, cardiac-only Timothy syndrome, SCD, personal history of aborted sudden cardiac death; Fam Hx, family history of disease in a 1st degree relative; Fam Hx SCD, family history of sudden cardiac death in a 1st degree relative.