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. Author manuscript; available in PMC: 2018 Dec 30.
Published in final edited form as: Hepatology. 2015 Feb;61(2):574–584. doi: 10.1002/hep.27543

Fig. 2.

Fig. 2.

Functional annotation of gene expression subtypes. (A) Hepatic stem cell markers were enriched in the gene signature and their expression significantly higher (2-fold or greater change in magnitude) in Cluster 1. Expression of AFP, which encodes a biomarker now in clinical use, was also higher in Cluster 1. (B) Gene set enrichment analysis indicated that a set of stem cell genes specific to liver cancer was most significantly enriched in Cluster 1, with an enrichment score of −0.79 (nominal P-value < 0.0001). (C) IL-8 and SOX4 were highly expressed in Cluster 1, with a difference in magnitude of 2-fold or greater and statistical significance (P < 0.0001). (D) High levels of IL-8 and SOX4 were associated with poorer overall survival than low levels.