Figure 1– HER2 promotes anoikis resistance.
Cell survival was analyzed in cells after 48h of anchorage independent conditions, using anoikis assay. A) Comparison of anoikis resistance in MDA-MB-231 and HH cells and in HH cells after silencing HER2 using shRNA transfection. B) Analysis of Anoikis resistance in SKBR3 and HER2 shRNA transfected SKBR3 cells. C) Bright field images of sulforhodamine B stained MDA-MB-231, HH and HH with HER2shRNA cells, re-attached after 48h of anchorage independent conditions. Values were plotted as mean ± SD (n=3).