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. 2018 Nov 2;293(52):20227–20239. doi: 10.1074/jbc.RA118.005579

Figure 7.

Figure 7.

Effect of exogenous LOC105374325 expression on podocyte injury in mice. A, PCR analysis of LOC105374325 in glomerular tissues of mice treated with control plasmid or LOC105374325-expressing plasmid; B, ISH analysis of LOC105374325 in glomerular tissues of mice (n = 6); C, periodic acid-Schiff staining of renal sections in mice (n = 6); D, urinary albumin excretion in mice (n = 6); E, level of pri-miR-34c and miR-34c in glomerular tissues of mice (n = 6); F, level of pri-miR-196a, miR-196a, pri-miR-196b, and miR-196b in glomerular tissues of mice (n = 6); G and H, RNA pulldown and RT-PCR analysis of the LOC105374325–miR-34c and LOC105374325–miR-196a/b complexes in glomerular tissues of mice (n = 6); I, IHC analysis of Bax and Bak in glomerular tissues of mice (n = 6); J, apoptotic podocytes in glomerular tissues of mice (n = 6). For statistical analysis, a two-tailed Student's t test was used for D, E, F, and J, and one-way ANOVA with Tukey's post hoc test was used for G and H. *, p < 0.05 compared with vehicle control mice. Bar, 20 μm.