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Effect of cprC disruption and overexpression on nikkomycin production. A, HPLC analysis of nikkomycin production in different strains. B, nikkomycin bioassays of fermentation filtrates from different strains. WT, S. ansochromogenes 7100. ΔcprC, disruption mutant of cprC. ΔcprCc, cprC complementary strain of ΔcprC. ΔsabA, sabA disruption mutant. ΔsabA/cprCoe, cprC overexpression strain in ΔsabA.
