Figure 4.

α7nAChR agonist treatment ameliorates STZ-induced diabetes in mice. A, weekly fed-blood glucose levels of STZ-induced or control mice subjected to daily injections of 10 mg/kg PNU-282987 or vehicle (4-week cohort). The mean values are indicated by red bars. B, PNU treatment improves glucose tolerance in MLDS mice as shown by IPGTT curves; and C, the corresponding area under curve (AUC) plots. All p values (using one-way analysis of variance) are indicated. The 4-day and 2-week cohorts were distinct from the mice used for the 4-week group. All groups, n = 5.