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. 2018 Nov 6;293(52):20123–20136. doi: 10.1074/jbc.RA118.005395

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© 2018 Mi et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 5. — The conditional expression of mouse Met transgene and homozygous Pten deletion induces a gene signature pattern that is associated with tumor progression. A, heat map of representative gene sets that are altered in Pten^L/L:PB-Cre4 and H11^Met/+/Pten^L/L:PB-Cre4 tumors. B, qRT-PCR validation of the gene expression in Pten^L/L:PB-Cre4 and H11^Met/+/Pten^L/L:PB-Cre4 tumors. The data are presented as the mean ± S.D. (error bars) for three independent samples. *, p < 0.05; **, p < 0.01; ***, p < 0.001. C, immunohistochemical analysis of SPP1 (C1 and D1), FN1 (C2 and D2), and N-cadherin (C3 and D3) expression in prostate tumors of Pten^L/L:PB-Cre4 and H11^Met/+/Pten^L/L:PB-Cre4 (D1–D3) mice.