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. 2018 Nov 6;293(52):20123–20136. doi: 10.1074/jbc.RA118.005395

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© 2018 Mi et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 6. — The conditional expression of mouse Met transgene and homozygous Pten deletion increases cell proliferation and migration in MEFs. A and B, wound-healing assay of MEFs. Shown are before (A) and after (B) images of scratches in the monolayer of Pten^L/L:CMVCreER-, Pten^L/L:CMVCreER⁺, and H11^Met/+/Pten^L/L:CMVCreER⁺ MEFs cultured in the absence/presence of HGF for 12 h. C, graphical representation of relative wound closure. The data represent quantifications of multiple images from two independent experiments ± S.D. D, graphical representation of cellular proliferation of Pten^L/L:CMVCreER⁻, Pten^L/L:CMVCreER⁺, and H11^Met/+/Pten^L/L:CMVCreER⁺ MEFs measured by MTS reduction. The data represent the mean ± S.D. of three independent experiments. E, qRT-PCR analysis of Met, Fn1, and Cdh2 expression in Pten^L/L:CMVCreER⁺ and H11^Met/+/Pten^L/L:CMVCreER⁺ MEFs. Bars, mean ± S.D. (error bars) of three independent experiments. *, p < 0.05; **, p < 0.01.