Table 1.

Pathological abnormalities of H11^Met/⁺/Pten^L/L:PB-Cre4 and Pten^L/L:PB-Cre4 mice

Genotype	<4 months	4–10 months	>10 months
PtenL/L:PB-Cre4	4 of 4 LGPIN	6 of 6 multifocal HGPIN	6 of 8 intracystic carcinoma
	2 of 4 multifocal HGPIN	2 of 6 intracystic carcinoma	4 of 8 adenocarcinoma
			3 of 8 invasive carcinoma
			1 of 8 invasive carcinoma with metastasisa
H11Met/+/PtenL/L:PB-Cre4	5 of 5 multifocal HGPIN	5 of 5 multifocal HGPIN	7 of 8 adenocarcinoma, 6 of 8 invasive carcinoma
		1 of 5 intracystic carcinoma	6 of 8 invasive carcinoma
		2 of 5 adenocarcinomas	5 of 8 invasive carcinoma with EMT
		1 of 5 invasive carcinoma	5 of 8 invasive carcinoma with metastasisb

^a Metastatic sites include lymph node and lung tissues.

^b Metastatic sites include lymph node, lung, and pancreas tissues.