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Rab protein prenylation pathway: Rab proteins require lipid modification (prenylation, highlighted as double yellow lines) to associate with membranes and organelles. REP1 mediates the initial step in the process by attaching to Rab proteins and facilitating interaction with geranyl–geranyl transferase 2 enzyme (GGTase2). GGTase 2 prenylates C-terminal cysteine motifs of Rabs and subsequently REP1 delivers modified Rab proteins to target intracellular compartment.
