Table 2. Results of histopathological evaluation of rat’s lung tissues, radiation group was compared to control group while radiation plus metformin group was compared to radiation group (a: significant compared to control group, ANOVA, Tukey's HSD, p<0.05).
Control | Metformin treated | Radiation | Radiation+Metformin | |
Macrophage infiltration | 1.00±00 | 1.00±00 | 3.66±0.57a | 1.5±0.57b |
Lymphocyte infiltration | 1.75±0.50 | 1.00±00 | 4.00±00a | 1.5±0.57b |
Neutrophil infiltration | 1.25±50 | 1.00±00 | 1.00±00 | 1.25±50 |
Alveolar thickness | 1.00±00 | 1.00±00 | 2.66±0.57a | 1.25±50b |
Vascular thickness | 1.00±00 | 1.00±00 | 2.00±00a | 1.00±00b |
Edema and thrombosis | 1.00±00 | 1.00±00 | 2.00±00a | 1.00±00b |