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. 2018 Oct 29;2018:6124745. doi: 10.1155/2018/6124745

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Copyright © 2018 Gloria Lazzeri et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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METH reduces the occurrence of the autophagoproteasome (APP) which hosts LC3, P20S, p62, and alpha-synuclein. (a) Representative immunofluorescence from controls and METH at 72 h. (b) Time-dependent graph of the number of LC3 + P20S-positive puncta per cell from control and METH at 1 μM. (c) P20S, p62, and alpha-synuclein Western blotting on LC3BI-II immunoprecipitates. (d) Densitometric analysis. Values are given as the optical density detected in four separate replicates (n = 4). Values are given as the mean number of LC3 + P20S puncta counted in 4 slides. Error bars represent the standard error of the mean. ^∗ p ≤ 0.05 vs. control. Arrows point to P20S (red fluorescence) or LC3 (green fluorescence) or merge P20S and LC3 (orange fluorescence). Scale bar = 6.6 μm.