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Sensitivity to MLN2283/ixazomib and LBH589/panobinostat combination treatment is dependent on the expression of GOF TP53. Sensitivity to MLN2238/ixazomib alone (a) or in combination with LBH589/panobinostat (b) was examined in parental Hec50 cells or Hec50 cells expressing the R175H GOF mutant. ∗∗∗P < 0.001 by two-way ANOVA with Sidak's multiple comparison test.
