Table 5.
Differentially expressed miRNAs in ZL-C versus ZO-C and ZL-C versus ZL-Rap pairwise comparisons that target differentially expressed cytokines in the corresponding pairwise comparisons and as determined by binding sites on the 3′ untranslated region of their mRNAs by in silico analysis in the corresponding sets.
| miRNA | Targeted cytokines increased in | miRNA | Targeted cytokines | |||
|---|---|---|---|---|---|---|
| ZO-C | ZL-Rap | Both | ZO-C | ZL-Rap | ||
| miR-21 | CTACK, PDGFAA, CINC2 | Notch2 | miR-350 | Notch2 | ||
| miR-411 | IL-2, IL-1α, TNF-α (2 sites) | IL-2, IL-10 | miR-505 | CINC2 | Gas1 | |
| miR-7a∗ | PDGFAA | IL-2, decorin, IL-22 | IL-10 | miR-217 | Notch 2, IL-1α | |
| miR-384-5p | IL-2, IL-10, Notch2 | miR-541 | Notch 2, CINC2 | |||
| miR-30e∗ | IL-22, Notch2 | IL-10, IFNγ | miR-328b-3p | Notch 2, Gas1 | ||
| miR-322 | IFNγ | miR-29b | Notch 2 | |||
| miR-382 | Notch2 | IFNγ, Prolactin | miR-455 | Notch2 | ||
| miR-742 | IFNγ | miR-34b | Gas1 | |||
| miR-539 | IFNγ | miR-19a | Gas1 | |||
| miR-329∗ | PDGFAA | Notch2 | IL-10 | miR-26b-3p | Gas1 | |
| miR-140 | Notch2 | IL-10, decorin | miR-429 | Gas1, Tim1 | ||
| miR-204 | TNF-α | Gas1 | IL-10 | miR-128-1-5p | Gas1 | |
| miR-98 | IL-1α | IL-10 | miR-144 | Gas1 | ||
| miR-665 | IL-10, Notch 2 (3 sites), Tim1 | miR-2985 | Gas1 | |||
| miR-335 | IL-10, Notch2, Tim 1 | miR-301a | Prolactin | |||
| miR-495 | IL-10 (2 sites), Notch 2, Gas1 (2 sites) | miR-362∗ | Tim1 | |||
| miR-338∗ | IL-10, Notch2 | miR-451∗ | Tim1 | |||
| miR-200b, c | Decorin | miR-409-5p | Tim1 | |||
| miR-223 | Decorin | miR-218a | Tim1 | |||
| miR-499 | Decorin (2 sites), Gas1 | miR-369-5p | Tim1 | |||
| miR-542-3p | Decorin, Tim1 | miR-434 | IL-22 | |||
| miR-138-1∗ | B7–1/CD80 | Notch2 | miR-379 | TREM1, FGF-BP | ||
| miR-196c | Decorin, TNF-α | miR-217 | Notch 2, IL-1α | |||
∗ indicates a functional but nonpredominant miRNA as indicated by miRbase.