. 2018 Dec 31;19(Suppl 1):215. doi: 10.1186/s12881-018-0721-7

Table 2.

Characteristics of 39 genetic variants in PD and AD GWAS datasets

SNP	Chr	Pos	Nearby Genes	EA	NEA	EAF^a	PD			AD GWAS
SNP	Chr	Pos	Nearby Genes	EA	NEA	EAF^a	Beta^b	SE	P value	Beta^b	SE	P value
rs10797576	1	232,664,611	SIPA1L2	T	C	0.127	0.113	0.014	8.41E-13	0.006	0.022	0.795
rs10906923	10	15,569,598	FAM171A1	A	C	0.461	0.073	0.014	1.35E-8	−0.033	0.017	0.051
rs11060180	12	123,303,586	OGFOD2	A	G	0.748	0.105	0.011	2.05E-20	0.032	0.019	0.081
rs11158026	14	55,348,869	GCH1	C	T	0.490	0.094	0.011	4.30E-16	−0.002	0.017	0.894
rs115185635	3	87,520,857	CHMP2B	C	G	0.012	0.191	0.048	1.22E-4	−0.022	0.058	0.702
rs11724635	4	15,737,101	FAM200B, CD38	A	C	0.408	0.105	0.011	1.22E-19	−0.032	0.016	0.040
rs117896735	10	121,536,327	BAG3	A	G	0.004	0.501	0.057	2.23E-19	0.133	0.086	0.119
rs12456492	18	40,673,380	SYT4	G	A	0.330	0.095	0.012	5.56E-16	0.009	0.017	0.589
rs12497850	3	48,748,989	NCKIPSD, CDC71	T	G	0.731	0.073	0.014	9.16E-9	0.028	0.017	0.088
rs12637471	3	182,762,437	MCCC1	G	A	0.663	0.163	0.015	2.11E-30	0.002	0.019	0.909
rs13294100	9	17,579,690	SH3GL2	G	T	0.457	0.083	0.014	4.84E-13	0.013	0.017	0.453
rs14235	16	31,121,793	ZNF646, KAT8	A	G	0.359	0.077	0.009	5.44E-12	0.041	0.016	0.011
rs1474055	2	169,110,394	STK39	T	C	0.201	0.186	0.018	5.68E-26	0.004	0.024	0.881
rs1555399	14	67,984,370	TMEM229B	T	A	0.607	0.086	0.012	9.61E-11	−0.021	0.016	0.194
rs199347	7	23,293,746	KLHL7, NUPL2, GPNMB	A	G	0.483	0.094	0.011	3.51E-18	−0.033	0.016	0.039
rs2280104	8	22,525,980	SORBS3, PDLIM2, C8orf58, BIN3	T	C	0.265	0.068	0.012	2.53E-8	−0.002	0.016	0.923
rs2414739	15	61,994,134	VPS13C	A	G	0.679	0.094	0.011	3.94E-14	−8.00E-04	0.017	0.964
rs2694528	5	60,273,923	ELOVL7	C	A	0.135	0.140	0.020	4.84E-15	−0.028	0.027	0.305
rs2740594	8	11,707,174	CTSB	A	G	0.893	0.086	0.012	5.91E-12	0.002	0.018	0.926
rs329648	11	133,765,367	MIR4697	T	C	0.465	0.086	0.012	1.11E-13	−0.007	0.018	0.701
rs34043159	2	102,413,116	IL1R2	C	T	0.332	0.077	0.009	5.48E-11	0.006	0.016	0.695
rs34311866	4	951,947	TMEM175,DGKQ	C	T	0.140	0.207	0.014	1.47E-50	0.009	0.021	0.685
rs353116	2	166,133,632	SCN3A	C	T	0.557	0.062	0.011	2.98E-8	0.038	0.016	0.021
rs356182	4	90,626,111	SNCA	G	A	0.404	0.285	0.012	5.21E-123	−0.056	0.017	0.001
rs35749011	1	155,135,036	GBA	A	G	0.005	0.545	0.044	2.59E-35	0.188	0.071	0.008
rs3793947	11	83,544,472	DLG2	G	A	0.570	0.073	0.011	3.72E-9	−0.010	0.016	0.525
rs4073221	3	18,277,488	SATB1	G	T	0.062	0.095	0.016	1.57E-8	0.007	0.023	0.754
rs4653767	1	226,916,078	ITPKB	T	C	0.726	0.083	0.011	1.63E-11	−0.005	0.017	0.756
rs4784227	16	52,599,188	TOX3	T	C	0.200	0.086	0.014	9.75E-11	−0.010	0.018	0.580
rs591323	8	16,697,091	MICU3	G	A	0.635	0.094	0.014	2.38E-11	−0.002	0.018	0.930
rs62120679	19	2,363,319	LSM7	T	C	0.426	0.077	0.014	6.64E-7	−0.004	0.022	0.843
rs6430538	2	135,539,967	TMEM163,CCNT2	C	T	0.189	0.117	0.011	8.24E-24	−0.047	0.017	0.006
rs6812193	4	77,198,986	FAM47E	C	T	0.687	0.083	0.011	1.43E-14	−0.017	0.016	0.310
rs76904798	12	40,614,434	LRRK2	T	C	0.132	0.140	0.015	1.21E-19	−0.016	0.022	0.483
rs78738012	4	114,360,372	ANK2, CAMK2D	C	T	0.039	0.122	0.018	4.78E-11	−0.012	0.029	0.680
rs8005172	14	88,472,612	GALC	T	C	0.434	0.077	0.012	8.77E-11	−0.021	0.016	0.171
rs8118008	20	3,168,166	DDRGK1	A	G	0.540	0.068	0.012	1.99E-6	0.014	0.018	0.432
rs823118	1	205,723,572	NUCKS1, SLC41A1	T	C	0.411	0.117	0.011	1.12E-23	−0.003	0.016	0.846
rs9468199	6	27,681,215	ZNF184	A	G	0.300	0.104	0.014	1.46E-12	0.044	0.022	0.046

SNP single-nucleotide polymorphism, Chr Chromosome, Pos Position, EA Effect Allele, NEA Non-Effect Allele, EAF Effect Allele Frequency, PD Parkinson’s disease, AD Alzheimer’s disease, GWAS genome-wide association studies, SE standard error

^aFrequency of the effect allele in 1000 Genomes Project (CEU)

^bBeta is the regression coefficient based on the effect allele. Beta > 0 and Beta < 0 means that this effect allele regulates increased and reduced PD or AD risk, respectively