Table 1.

The 18 PPIs datasets used in this paper

Groups	Datasets	# Positive samples	# Negative samples
SC a	SC-SS 1	17257	17257
	SC-RW 2	17257	17257
	SC-Sub 3	17257	17257
	SC-RP 4	17257	17257
HS b	HS-SS	3355	3355
	HS-RW	3355	3355
	HS-Sub	3355	3355
	HS-RP	3355	3355
MM c	MM-SS	923	923
	MM-RW	923	923
	MM-Sub	923	923
	MM-RP	923	923
Test d	C. elegans	4013	0
	E. coli	6984	0
	H. sapiens	1412	0
	H. pylori	1420	0
	M. musculus	313	0
	Mammalian	0	1937

^aSC: S. cerevisiae;

^bHS: H. sapiens;

^cMM: M. musculus;

^dTest: Six independent testing datasets;

¹NIP-SS;

²NIP-RW;

³Subcellular location;

⁴Random pairing