Table 8.

Results based on different negative datasets on S. cerevisiae, H. sapiens and M. musculus

Species	Negative samples	ACC	PE	RE	SPE	MCC	F 1	AUC
S. cerevisiae	NIP-SS	94.34% ± 0.38%	95.62% ± 0.75%	92.96% ± 0.40%	95.74% ± 0.75%	88.73% ± 0.77%	94.27% ± 0.34%	98.24% ± 0.11%
	NIP-RW	87.92% ± 0.24%	90.04% ± 1.69%	85.32% ± 1.90%	90.48% ± 2.20%	75.97% ± 0.55%	87.59% ± 0.35%	94.23% ± 0.12%
	Sub	93.79% ± 0.43%	95.18% ± 0.41%	92.25% ± 0.78%	95.33% ± 0.45%	87.62% ± 0.83%	93.69% ± 0.38%	98.13% ± 0.17%
	Random method	74.20% ± 0.78%	72.68% ± 1.45%	77.59% ± 0.89%	70.83% ± 1.77%	48.53% ± 1.47%	75.04% ± 0.76%	81.29% ± 0.34%
H. sapiens	NIP-SS	86.17% ± 0.93%	86.38% ± 1.27%	85.88% ± 1.55%	86.48% ± 1.00%	72.36% ± 1.85%	86.12% ± 1.05%	92.20% ± 0.82%
	NIP-RW	86.44% ± 0.59%	90.05% ± 0.48%	81.87% ± 2.35%	90.91% ± 1.09%	73.14% ± 1.12%	85.75% ± 1.28%	92.30% ± 0.70%
	Sub	93.34% ± 0.58%	93.19% ± 0.42%	93.51% ± 0.94%	93.17% ± 0.37%	86.68% ± 1.16%	93.35% ± 0.57%	96.22% ± 0.45%
	Random method	60.46% ± 1.54%	60.07% ± 1.74%	62.33% ± 1.91%	58.50% ± 3.24%	20.85% ± 3.14%	61.17% ± 1.63%	64.57% ± 1.35%
M. musculus	NIP-SS	81.69% ± 1.48%	80.57% ± 2.20%	83.73% ± 2.97%	79.51% ± 4.47%	63.44% ± 3.16%	82.06% ± 0.84%	87.04% ± 1.95%
	NIP-RW	80.66% ± 2.14%	84.89% ± 5.41%	74.83% ± 3.46%	86.72% ± 4.62%	61.97% ± 4.53%	79.41% ± 2.52%	87.75% ± 2.25%
	Sub	91.82% ± 1.26%	90.13% ± 2.57%	93.93% ± 2.38%	89.76% ± 2.41%	83.78% ± 2.40%	91.95% ± 1.44%	94.81% ± 0.74%
	Random method	50.76% ± 2.12%	50.80% ± 5.77%	52.17% ± 1.90%	49.44% ± 3.26%	1.60% ± 3.86%	51.37% ± 3.58%	51.40% ± 2.43%