Table 3.
Transcription factors enriched in AD-specific modules that showed differentially expressed between AD and normal brain samples
| Differentially expressed TFs | Module name | TF target genes in the module |
|---|---|---|
| FOS | AD_M5 | MED12;IL11;GPR34;DOCK8;MRC1;PLA2G7 |
| JUN | AD_M3 | FBXW4;NOTCH4;HDAC11;PLEKHB1;ICAM2;CABLES1;WDR83;GAB2;PTH1R;FGF1;AIF1L;TGFBR2;TM7SF2;KIAA1598;GNA12;PROM1;KANK3;BOK;TBC1D16 |
| SP1 | AD_M1 | DDR1;SLC27A1;LEPROT;MAOA;HDAC11;NDRG2;TRIM8;LFNG;CCND3;ZNRF3;NACC2;SH3PXD2B;UAP1L1;PRDM16;LRIG1;PLCG1;ARHGEF40;NEO1;RREB1;TBC1D16;NKX2–2;MYO10;PAX6;GRIN2C;PRDX6;ERBB2IP;ZFP41;RFX4;DLC1;PPP1R1B;PLXNB1;PLEKHO2;PPARA;MEGF8;EZR;FGFR3 |
| ZFHX3 | AD_M25 | FAM122B;RSAD2;OAS1;SAMD9;TRIM21;USP18;IFIT3 |
| ZNF281 | AD_M1 | DDR1;PPP1R14B;ADCYAP1R1;PHLPP1;SLC44A2;MAOA;WFS1;PBXIP1;NDRG2;TRIM8;ERBB2IP;TUBB2B;DLC1;TRPS1;NACC2;PPP1R1B;PRDM16;ITGA6;PLEKHO2;NEO1;RREB1;GPR125;RAPGEF3 |
| TEAD4 | AD_M1 | ADCYAP1R1;LEPROT;MAOA;AQP4;NDRG2;NPAS3;PHF21B;LFNG;SOX2;CCND3;SLC25A29;ZNRF3;GNA12;SH3PXD2B;UAP1L1;PLCG1;SOX9;CCDC77;ARHGEF40;NEO1;RREB1; |
| NKX2–2;SNTA1;PAQR6;YES1;MYO10;WFS1;C17ORF62;GRIN2C;PRDX6;PLEKHA7;GADD45G;KIAA1755;ZFP41;FAM195B;RFX4;DLC1;PPP1R1B;PLEKHO2;PPARA;MEGF8;EZR | ||
| MIB2 | AD_M1 | SLC27A1;ALDH1L1;COL16A1;TTYH1;PON2;MED12L;EGFR;LFNG;SLC25A29;HEPH;PERP;NACC2;SH3PXD2B;PHACTR3;S100A13;KCNN3;ACSS1;ARHGEF40;PAMR1;RREB1;STOX1;ZNF462;PPP1R14B;SERPINB1;PAX6;C17ORF62;PLEKHA7;AIF1L;ZFP41;DLC1;PMP22;MEGF8;SFXN5;ITM2C |
| MEF2A | AD_M12 | NR4A2;TNMD;GPR64;TMEM74;SAMD3;TTN |
| PCBP1 | AD_M1 | DDR1;SLC27A1;LEPROT;SDC4;MAOA;AK4;NDRG2;NPAS3;CCND3;ZNRF3;NACC2;SH3PXD2B;PRDM16;UAP1L1;LRIG1;PLCG1;ARHGEF40;NEO1;RREB1;CD99;TBC1D16;TMEM184B;GPT2;PAX6;GRIN2C;PRDX6;ERBB2IP;GLUD1;FAM195B;ZFP41;DLC1;PLXNB1;PLEKHO2;PPARA;MEGF8;EZR;FGFR3;ZNF652 |
| SMARCA2 | AD_M14 | FOXC2;SLC38A1;FOXD2;CRABP2;LRP1;CCDC25;PLA2G2A;KCTD9;KLF5;OS9;PPDPF;P4HB;SLC22A8;PHLDB2;PTGDR |
| STAT1 | AD_M14 | DSP;CLIC3;CRABP2;LRP1;PRDM6;CXCR4;BMP4;COL3A1;COL1A2;PDLIM2;MLPH;NOV;SLPI;SPTLC3;FRZB;PPDPF;SLC26A7 |