Table 4.
Transcription factors enriched in normal-specific modules that showed differentially expressed between AD and normal brain samples
| Differentially expressed TFs | Module name | TF target genes in the module |
|---|---|---|
| BCL6 | N_M9 | CSRNP3;RBFOX2;UBE2R2;THRAP3;NRXN1;OTUD7A;FNIP2 |
| BCL6 | N_M13 | TRPC3;RSPO2;BTBD11;ITM2A;HS3ST1 |
| JUND | N_M9 | GABRA1;CSRNP3;UBE2R2;CCNY;NRXN1;GTPBP8;RUNX1T1 |
| JUND | N_M30 | CFH;C1S;MS4A4A;TNFSF13B |
| REPIN1 | N_M9 | MYLIP;RBFOX2;CCNY;RAB14;GABRA4;KLHL8;KIF1A;SRCIN1 |
| CBFB | N_M11 | DSP;CAMK2D;PTGER3;ARHGAP6 |
| TCF4 | N_M12 | CLEC3B;CD163;COL1A2;SLC13A4;C7;C1S;ADH1B;OGN;FBLN1;CD14;CES1 |
| TCF4 | N_M24 | GSTM3;SLC13A4;C2ORF40;LRRC18;GOLM1;KCNJ13;SERPINF1;TYRP1;ABCA4;BUB1B;HTR2C;FBLN1;SULF1;CLDN2;PRLR;LOXL1;GHR;SLCO1B3;SOSTDC1;OTX2;HPD |
| EGR1 | N_M15 | WWC3;CORO6;UPP1;FRS3 |
| SOX10 | N_M23 | RGS2;ALKBH5;SNX16;BDNF;HS3ST2 |
| ZBTB7A | N_M25 | EGR2;NR4A3;FOSB;SIK1;FOS;JUNB |
| APEX1 | N_M28 | IGBP1;CLCN4;PHF20;UBE2D3;ZNF12 |