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. Author manuscript; available in PMC: 2018 Dec 31.
Published in final edited form as: Biochem Soc Trans. 2018 Dec 4;46(6):1697–1705. doi: 10.1042/BST20180468

Figure 2. Potential pre- and postsynaptic mechanisms by which mutant LRRK2 can influence synaptic function.

Figure 2.

Cartoon depicts a glutamatergic synapse and highlights possible sites of LRRK2-G2019S interaction/interference with the normal processes of presynaptic vesicle recycling and insertion of new CP-AMPA receptor subunits into the plasma membrane. CP: calcium permeable; LRRK2-mut: PD-causing LRRK2 mutations, particularly G2019S.