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. 2018 Dec 20;104(1):13–24. doi: 10.3324/haematol.2018.196105

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Figure 1. — Comparison of developmental hematopoiesis in humans and zebrafish. Primitive and definitive hematopoiesis occurs in both species. In human, hematopoietic stem cells (HSC) originate in aorta-gonad-mesonephros (AGM) and placenta, from where they colonize fetal liver and finally the bone marrow. In zebrafish, primitive hematopoiesis starts after hemangioblast formation around 12 hpf in the anterior lateral mesoderm (ALM) and posterior lateral mesoderm (PLM). Later, HSCs originate in the AGM and then mobilize to caudal hematopoietic tissue (CHT) prior to their final destination of the kidney (modified from Teittinen et al.¹² and de Jong and Zon¹⁴).