Figure 2.
Suggested approach to central nervous system risk stratification and prophylaxis in newly diagnosed diffuse large B-cell lymphoma. DLBCL: diffuse large B-cell lymphoma; CNS-IPI: Central Nervous System International Prognostic Index; DHL: double-hit lymphoma; COO: cell of origin; ABC: activated B-cell; DEL: double-expressing lymphoma; THL: triple-hit lymphoma; LP: lumbar puncture; MRI: magnetic resonance imaging; CNS: central nervous system; CSF: cerebrospinal fluid; MTX: methotrexate; CrCl: creatine clearance; HD-MTX: high-dose methotrexate; IT-MTX: intrathecal methotrexate.