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. Author manuscript; available in PMC: 2018 Dec 31.
Published in final edited form as: J Am Chem Soc. 2018 Apr 25;140(18):6027–6032. doi: 10.1021/jacs.8b03071

Scheme 1.

Scheme 1.

Preparation of [15N2]-2,4-Dimethoxy-6-bromopyrimidine and [15N3]-Guanidine Hydrochloride from 15NH4Cl, the Key Precursors Constituting the Source of All 15N Isotopes in Cylindrospermopsins