Algorithm 1: Diagnostic

$$\begin{array}{cc}\hfill & \mathrm{Input}:\text{Cohort1 T0,T1 and Cohort2 T1,T2 Radiomics}\hfill \\ \hfill & \text{features}\in \{\mathit{Definiens},\mathit{Rider},\mathit{PyRadiomics}\}\hfill \\ \hfill & \mathrm{Output}:\text{Diagnostic model}\hfill \\ \hfill & \mathbf{Computer}\mathrm{Delta}:\text{Let Cohort1 T0,T1 be}C1T0,C1T1,\hfill \\ \hfill & \begin{array}{c}\text{and Cohort2 T1, T2 be}C2T1,C2T2.\hfill \\ C{1}_{\mathit{delta}}=C1T1-C1T0,\text{and}\hfill \\ C{2}_{\mathit{delta}}=C2T2-C2T1\hfill \end{array}\hfill \\ \hfill & 1)\mathrm{Initialization}:\hfill \\ \hfill & \text{Let train set}{\mathit{Train}}_{\mathit{noDelta}}\text{be}C1T1\text{and}{\mathit{Test}}_{\mathit{noDelta}}\text{be}\hfill \\ \hfill & \begin{array}{c}C2T2.\text{Let train set (after union with delta) be}\hfill \\ {\mathit{Train}}_{\mathit{withDelta}}=\text{union}(C1T1,C{1}_{\mathit{delta}})\text{and test set}\hfill \\ \text{(after union with delta)}\text{be}{\mathit{Test}}_{\mathit{withDelta}}=\hfill \\ \text{union}(C2T2,C{2}_{\mathit{delta}}).\hfill \end{array}\hfill \\ \hfill & 2)\mathbf{Training}\mathbf{and}\mathrm{Testing}:\hfill \\ \hfill & \text{A) Train a classifier on}{\mathit{Train}}_{\mathit{noDelta}}\text{and test on}\hfill \\ \hfill & {\mathit{Test}}_{\mathit{noDelta}}\text{and report accuracy and AUC}.\hfill \\ \hfill & \text{B) Train a classifier on}{\mathit{Train}}_{\mathit{withDelta}}\text{and test on}\hfill \\ \hfill & {\mathit{Test}}_{\mathit{withDelta}}\text{and report accuracy and AUC}.\hfill \end{array}$$