. Author manuscript; available in PMC: 2019 Nov 29.

Published in final edited form as: IEEE Access. 2018 Nov 29;6:77796–77806. doi: 10.1109/ACCESS.2018.2884126

TABLE 8:

Classifiers, features used, and performance statistics for best AUC of risk prediction model (experiment 2) using RIDER features

Experiment	Features Set	Classifier	Feature Selector	Features Selected	Performanc Statistics
Experiment	Features Set	Classifier	Feature Selector	Features Selected	AUC (95% CI)	Specificity (95% CI)	Sensitivity (95% CI)
Train C1T1 & Test C2T1	Rider features	Random Forests	ReliefF (15)	Mean [HU], Roundness, StdDev [HU], 8a_3D_Is_Attached_To_Pleural_Wall, 3D Laws features L5 W5 L5 Layer 1, 9b_3D_Circularity, Asymmetry, 1Longest Diameter [mm], Short Axis [mm], 9g_3D_MAX_Dist_COG_To_Border_[mm], 3D Laws features E5 E5 R5 Layer 1, 8c_3D_Relative_Border_To_PleuralWall, 8b_3D_Relative_Border_To_Lung, 3D Laws features E5 W5 L5 Layer 1, 9e_3D_SD_Dist_COG_To_Border_[mm]	0.773 (0.74-0.81)	0.89 (0.84-0.93)	0.56 (0.46-0.65)
Train on C1T1 and C1 delta features & Test on C2T1 and C2 delta features (i.e., C2T1 - C2T0)	Rider features	Random Forests	ReliefF (20)	Mean [HU],Roundness, 9b_3D_Circularity, Longest Diameter [mm], Short Axis [mm], 9g_3D_MAX_Dist_COG_To_Border_[mm], 8a_3D_Is_Attached_To_Pleural_Wall, 3D Laws features L5 W5 L5 Layer 1, Asymmetry, 3D Laws features E5 E5 R5 Layer 1, 9e_3D_SD_Dist_COG_To_Border_[mm], 8c_3D_Relative_Border_To_PleuralWall, 8b_3D_Relative_Border_To_Lung, Short Axis * Longest Diameter [mm_], 9g 3D MAX Dist COG To Border [mm] Delta, Asymmetry_Delta, ShortAxis[mm]_Delta, StdDev[HU]_Delta, Mean[HU]_Delta, LongestDiameter[mm]_Delta	0.822 (0.79-0.85)	0.93 (0.89-0.96)	0.49 (0.40-0.59)
p value (p <0.05)					0.303