Table 2. Total histological modified scale scores.

	4 weeks				12 weeks
	PLGA	PLGA+G	PLGA+HA	PLGA+G+HA	PLGA	PLGA+G	PLGA+HA	PLGA+G+HA
Overall filling	0.83±0.6	1.7±0.3	1.9±0.1	2.5±0.3a	1.8±0.4	2.5±0.3	2.3±0.3	2.7±0.3
Bone filling	0.25±0.25	1.1±0.1a	1.6±0.3a	2.8±0.3bde	1.3±0.3	2.2±0.4	2.3±0.3a	2.9±0.1b
Subchondral morphology	0.5±0.3	0.6±0.3	1.3±0.3	2.4±0.2bde	1.3±0.3	2.1±0.5#	2.9±0.3a#	3.2±0.2b#
Bone bonding	0.4±0.2	1.2±0.4	1.7±0.7	2.6±0.6a	1.9±0.6	2.1±0.7	2.5±0.7	3.3±0.4
Surface morphology	1.3±0.7	3.3±1.2	3.5±0.3a	4.3±0.9a	3.0±0.6	3.8±0.4	4.2±0.7	5.2±1.1
Cartilage thickness	0.17±0.2	2.4±0.8	2.5±0.8a	2.4±0.9	2.2±1.2	2.1±1.2	3.2±1.5	3.1±1.5
Surface regularity	0.7±0.3	1.8±0.6	1.2±0.2	2.1±0.6	1.7±0.3	1.4±0.3	2±0.6	2.6±0.3c
Chondrocyte clustering	0.1±0.1	2.0±0.6a	1.0±0.0b	1.8±0.2be	0.9±0.5	1.8±0.4	1.9±0.1*	2.8±0.3ace#
GAG and cell content of neo-surface	0.2±0.2	1.5±0.3a	1.3±0.3a	1.8±0.2b	1.1±0.1	1.5±0.3#	1.9±0.1b	2.3±0.3ac
GAG and cell content of adjacent surface	0.5±0.3	1.3±0.4	1.8±0.3a	1.8±0.2ad	1.8±0.3	1.3±0.3#	1.7±0.4	2.8±0.3ade#
Total PLGA degradation	4.9±1.3 0.2±0.1	16.8±1.1b 0.7±0.3	17.7±1.8b 1.2±0.2a	24.5±1.5be 3.0±0.0b	16.9±2.9# 0.8±0.2d	21.7±2.4# 2.5±0.3bd*	24.8±1.9a# 2.2±0.1b#	30.1±1.2ace# 3.0±0.0b

Values were expressed as mean±standard error of the mean for each parameter

^aCompared with the PLGA group at the same time point (p<0.05).

^bCompared with the PLGA group at the same time point (p<0.01).

^cCompared with the PLGA+G group at the same time point (p<0.05).

^dCompared with the PLGA+G group at the same time point (p<0.01).

^eCompared with the PLGA+HA group at the same time point (p < 0.05).

^fCompared with the PLGA+HA group at the same time point (p<0.01).

^#Compared to 4 weeks postoperatively (p<0.05).

*Compared to 4 weeks postoperatively (p<0.01).