Table 2. The new associations between Schistosoma mansoni energy metabolism targets and drugs identified in the present study.
| Drug name | Drug category | Drug toxicity | IDa and S. mansoni target name | E-valueb |
|---|---|---|---|---|
| (DB00730) Thiabendazole | Anthelmintic | High dosage may be associated with transient vision and psychological disturbances. The oral LD50 is 3.6 g/kg, 3.1 g/kg, and 3.8 g/kg in mice, rats, and rabbits, respectively | (Smp_061230) Succinate dehydrogenase | 4.68425e-121 |
| (DB00518) Albendazole | Anthelmintic | Overdose symptoms include increased liver enzymes, headaches, hair loss, low white blood cell count (neutropenia), fever, and itching | (Smp_061230) Succinate dehydrogenase | 2.31889e-25 |
| (DB01213) Fomepizole | Antidote | Headaches, nausea, and dizziness | (Smp_044440) Alcohol dehydrogenase | 5.95631e-125 |
| (DB01189) Desflurane | Anesthetic | Unavailable | (Smp_082120) ATP synthase delta chain, mitochondrial | 2.72872e-44 |
| (DB00753) Isoflurane | Anesthetic | LC50 = 15300 ppm/3 hours (inhalation per rat) | (Smp_082120) ATP synthase delta chain, mitochondrial | 2.72872e-44 |
| (DB00630) Alendronate |
Anti-hypokalemic | Damages the esophagus not only because of the medicine's toxicity but non-specific irritation secondary to contact between the pill and the esophageal mucosa, similar to other "esophagitis pill" cases | (Smp_038100) ATP synthase beta-subunit | 1.35936e-21 |
| (DB01119) Diazoxide | Antihypertensive | LD50 orally: 980 mg/kg for rats and 444 mg/kg for mice | (Smp_091460) Glutamine synthetase 1, 2 (glutamate ammonia ligase) (gs) | 3.91448e-180 |
aID–Target identity
bE-value–Expectation value