Table 1. KEGG pathways enriched by proteins that were identified as dose-only dependent and/or age-only dependent in the backward stepwise regression model selection procedure.
The pathways common for dose-only and age-only dependent proteins are placed in the middle.
| Age-dependent | Dose-dependent | |
|---|---|---|
| Fatty acid elongation | PI3K-Akt signalling pathway | Ribosome |
| Tryptophan metabolism | Pathogenic Escherichia coli infection | Carbon metabolism |
| Protein processing in endoplasmic reticulum | Glyoxylate and dicarboxylate metabolism | |
| Biosynthesis of amino acids | Arrhythmogenic right ventricular cardiomyopathy | |
| Proteasome | Pyruvate metabolism | |
| Dose-age-dependent | Tight junction | Butanoate metabolism |
| Metabolic pathways | Glycolysis/Gluconeogenesis | Adrenergic signalling in cardiomyocytes |
| Cardiac muscle contraction | Peroxisome | AMPK signaling pathway |
| Propanoate metabolism | Leukocyte transendothelial migration | Vasopressin-regulated water reabsorption |
| Valine, leucine and isoleucine degradation | Fatty acid metabolism | Beta-Alanine metabolism |
| Hypertrophic cardiomyopathy | ECM-receptor interaction | Antigen processing and presentation |
| Dilated cardiomyopathy | PPAR signalling pathway | Phagosome |
| Oxidative phosphorylation | Fatty acid degradation | TCA cycle |
| Porphyrin and chlorophyll metabolism | 2-Oxocarboxylic acid metabolism | |
| Focal adhesion | ||