Table 2.
IC50 |
||||
---|---|---|---|---|
A Translation inhibitiona | 1 | 2 | 6 | 9 |
FF luciferase | 0.95 ±0.05 | 0.33±0.10 | 30.40 ±2.56 | 1.31±0.03 |
Ren luciferase | 3.54±0.62 | 0.39±0.30 | >50 | 7.05±0.80 |
IC50 |
||||
B Cytotoxicityb | 1 | 2 | 3 | |
MDA-MB-231 | 0.3 ±0.02 | 0.33 ±0.01 | 2.28±0.07 | |
Du145 | 1.86 ± 0.06 | 2.21 ±0.05 | >10 | |
HCT-15 | 0.82 ±0.04 | 0.86 ±0.03 | >10 | |
MCF7 | 0.28±0.01 | 0.31 ±0.01 | 2.47 ±0.07 |
Abbreviations: FF, firefly; Ren, renilla.
Substrate for the translation inhibition assay was capped-(CAG)33FF/HCV/RenpA51 mRNA.
All other compounds showed no detectable inhibition at 20μm.
All other compounds showed no detectable toxicity at 10 μm.