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. 2018 Nov 22;597(1):303–317. doi: 10.1113/JP276400

Figure 2. ATP evokes currents in inner sulcus supporting cells.

Figure 2

A, 100 μm ATP evoked inward currents in an IS cell. Voltage command ramps were applied every 60 s. Cells were held at a command potential of −55 mV. Below, I–V plot with command ramps (at 0.27 mV/ms) returned towards pre‐ATP application levels. Each of the ramps shown in detail corresponds to a ramp indicated by a red dot shown in the traces. B, in the presence of 1 mm 1‐octanol, the response to ATP was shortened with no long‐lasting change in membrane current. C, box plot of input slope conductance, gm, at I = 0 from I–V curves. Columns show before ATP (n = 22), 60 s after ATP (n = 20) and in the presence of 1 mm octanol (n = 6). The effect of ATP was to reduce the mean conductance by 11‐fold.